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Anesth Analg 1986; 65:1196-1200
© 1986 International Anesthesia Research Society
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Cerebral Arteriovenous Oxygen Content Difference during Barbiturate Therapy in Patients with Acute Brain Damage

Atsuo Sari, MD, Yasutoshi Matayoshi, MD, Akitomo Yonei, MD, Hiroko Ogasahara, MD, Tadahiko Nonoue, MD, Kimio Yokota, MD, and Shigeki Yamashita, MD

Department of Anesthesia, Kurashiki Central Hospital, Okayama, Japan.

Abstract

This study evaluated the reliability of cerebral blood flow equivalent (CBFE), which was calculated as the reciprocal of cerebral arteriovenous oxygen content difference (C(av)DO2) as a monitor during barbiturate therapy in patients with cerebral ischemic insults. A barbiturate (thiamylal) was administered at a rate of 3 mg·kg 1·hr–1 for 2–5 days to four patients who had suffered cardiac arrest, four with acute focal ischemia, two with postoperative brain edema after neurosurgery, and one with brain damage due to asphyxia. Four of the 11 patients completely recovered sequelae or died (nonrecovery group). The mean value of CBFE in the recovery group decreased significantly with barbiturate therapy to 13 ± 1 ml blood/ml O2 from 39 ± 3 ml blood/ml O2 but did not decrease in the nonrecovery group. We conclude that CBFE can be useful for monitoring the effect of barbiturate therapy in ischemic brain insults.

Key Words: BRAIN, COMA—barbiturate therapy • HYPNOTICS, BARBITURATES—brain injury






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.