JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Burm, A. G. L. Articles by Spierdijk, J. Search for Related Content PubMed PubMed Citation Articles by Burm, A. G. L. Articles by Spierdijk, J.

Epidural Anesthesia with Lidocaine and Bupivacaine

Effects of Epinephrine on the Plasma Concentration Profiles

Received from the Department of Anesthesiology, University Hospital, Leiden, The Netherlands.

Abstract

The effects of epinephrine on the plasma concentrations and derived pharmacokinetic parameters were studied after epiditral administration of lidocaine and bupivacaine. Addition of epinephrine to the local anesthetic solutions reduced the mean peak plasma concentrations of lidocaine and bupivacaine from 2.2 to 1.7 µg/ml (23%) and from 0.73 to 0.53 µg/ml (28%), respectively, but did not alter the times at which the peak concentrations were reached. Epinephrine also did not alter the terminal half-lives or the total plasma clearances. The results suggest that addition of epinephrine to minimize plasma concentrations is as relevant with bupivacaine as it is with lidocaine.

Key Words: ANESTHETIC TECHNIQUES, EPIDURAL. • ANESTHETICS, LOCAL—lidocaine, bupivacaine. • PHARMACOKINETICS—lidocaine, bupivacaine.

This article has been cited by other articles:

				G. L. Bryson, C. Thompson, S. Gagne, L. Byford, J. Penning, and M. Kattan The addition of adrenaline to thoracic epidural meperidine does not improve analgesia following thoracotomy: [L'ajout d'adrenaline a la meperidine peridurale thoracique n'ameliore pas l'analgesie a la suite d'une thoracotomie] Can J Anesth, November 1, 2007; 54(11): 882 - 890. [Abstract] [Full Text] [PDF]

				T. Kawasaki, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice Am J Physiol Cell Physiol, November 1, 2006; 291(5): C1049 - C1055. [Abstract] [Full Text] [PDF]

				T. Kawasaki, C. Kawasaki, M. Ogata, and A. Shigematsu The Effect of Local Anesthetics on Monocyte mCD14 and Human Leukocyte Antigen-DR Expression Anesth. Analg., April 1, 2004; 98(4): 1024 - 9. [Abstract] [Full Text] [PDF]

				P. Radovic, R. G. Smith, and D. Shumway Revisiting Epinephrine in Foot Surgery J Am Podiatr Med Assoc, March 1, 2003; 93(2): 157 - 160. [Abstract] [Full Text] [PDF]

				B. B. Lee, W. D. Ngan Kee, J. L. Plummer, M. K. Karmakar, and A. S.Y. Wong The Effect of the Addition of Epinephrine on Early Systemic Absorption of Epidural Ropivacaine in Humans Anesth. Analg., November 1, 2002; 95(5): 1402 - 1407. [Abstract] [Full Text] [PDF]

				M. Miyabe, Y. Kakiuchi, S. Inomata, Y. Ohsaka, Y. Kohda, and H. Toyooka Epinephrine does not reduce the plasma concentration of lidocaine during continuous epidural infusion in children: [L'epinephrine ne reduit pas la concentration plasmatique de lidocaine pendant une perfusion peridurale continue chez les enfants] Can J Anesth, August 1, 2002; 49(7): 706 - 710. [Abstract] [Full Text] [PDF]

				G. Niemi and H. Breivik Epinephrine Markedly Improves Thoracic Epidural Analgesia Produced by a Small-Dose Infusion of Ropivacaine, Fentanyl, and Epinephrine After Major Thoracic or Abdominal Surgery: A Randomized, Double-Blinded Crossover Study With and Without Epinephrine Anesth. Analg., June 1, 2002; 94(6): 1598 - 1605. [Abstract] [Full Text] [PDF]

				D. J. Kopacz, J. D. Helman, C. E. Nussbaum, J. N. K. Hsiang, P. C. Nora, and H. W. Allen A Comparison of Epidural Levobupivacaine 0.5% With or Without Epinephrine for Lumbar Spine Surgery Anesth. Analg., September 1, 2001; 93(3): 755 - 760. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999