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Anesth Analg 1986; 65:1300-1302
© 1986 International Anesthesia Research Society
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Acetaldehyde Syndrome after Celiac Plexus Alcohol Block

Junko Noda, MD, Shinichiro Umeda, MD, Kenjiro Mori, MD, Tatsushige Fukunaga, MD, and Yasuhiko Mizoi, MD

Received from the Department of Anesthesiology, Faculty of Medicine, Kyoto University, and the Department of Legal Medicine, Faculty of Medicine, Kobe University, Kobe, Japan.

Abstract

In the course of celiac plexus alcohol block, facial flushing, palpitations, and hypotension are occasionally incurred in some patients. We hypothesized that the phenomenon represents acetaldehyde syndrome, not response to increased blood levels of ethanol as might be supposed. In order to prove our hypothesis, we selected five patients scheduled to undergo celiac plexus alcohol block, and, with their consent, we measured blood concentration of ethanol and acetaldehyde before and for 6 hr after the block. We also determined the phcnotypes of aldehyde dehydrogenase (ALDH) in their hair roots. We found that "flushers" are found exclusively among subjects without ALDH I, and that their blood levels of acetaldehyde were significantly higher than those of "non-flushers" within 10 min after the block. The flushers also gave histories of facial flushing after ingestion of small amounts of ethanol. On the basis of such histories one can anticipate whether acetaldehyde syndrome is likely or unlikely to accompany the block.

Key Words: ALCOHOL—nerve blocks. • METABOLISM—acetaldehyde syndrome.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.