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Anesth Analg 1986; 65:1324-1328
© 1986 International Anesthesia Research Society
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Retrobulbar Anesthesia

The Role of Hyaluronidase

J. Martin V. Nicoll, FFASA, Beatrix Treuren, FFARACS, P. Arun Acharya, FFARCS, Kjell Ahlen, MD, and Michael James, FFARCS

Received from the Department of Anesthesia, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Abstract

The present study was conducted in 100 patients receiving retrobulbar block for ophthalmic surgery to compare the efficacy of local anesthetic solutions with and without hyaluronidase. All patients received 3.5 ml of a mixture of 3 ml of 0.5% bupivacaine and 2 ml of 2% lidocaine. Seventy-five international units of hyaluronidase were diluted in 5 ml of the local anesthetic mixture and used for 50 of the blocks. The remainder did not receive hyaluronidase. A consistently better motor blockade was achieved with hyaluronidase (P < 0.001 at 10, 15, and 20 min). This finding has not been conclusively demonstrated before.

Key Words: ANESTHESIA—ophthalmologic. • ANESTHETIC TECHNIQUES, REGIONAL—retrobulbar.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.