JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kien, N. D. Articles by Eisele, J. H. Search for Related Content PubMed Articles by Kien, N. D. Articles by Eisele, J. H., Jr

Cardiovascular Function during Controlled Hypotension Induced by Adenosine Triphosphate or Sodium Nitroprusside in the Anesthetized Dog

Department of Anesthesiology, University of California, School of Medicine, Davis, California.

Abstract

The present study was undertaken to compare the hemodynamic effects of adenosine triphosphate (ATP) and sodium nitroprusside (NP) given in equieffective doses to induce hypotension during halothane anesthesia. Eight dogs, instrumented with pressure and ultrasonic dimension transducers for assessment of left ventricular (LV) performance, were given both NP and ATP. Regional blood flow was measured by radioactive microspheres. After 20 min of infusion, both drugs decreased systemic arterial pressure by 36% with minimal changes in cardiac index (CI), LV end-diastolic pressure, or heart rate. However, hypotension produced by ATP was associated with a greater CI (3.84 ± 0.32 vs 2.97 ± 0.35 L·min^–1·m^–2) than was NP and also associated with a further decrease in systemic vascular resistance (14.4 ± 1.4 vs 17.7 ± 2.2 mm Hg·L^–1·min·m²). Left ventricular global function, measured by the slope of the linear regression line of the LV end-systolic pressure-diameter relation (Ees.), did not change significantly after either drug. Blood flow to the coronary bed was significantly greater with ATP than with NP (231.6 ± 30.6 vs 81.7 ± 6.1 ml·min^–1·100 g^–1). Except for an increase in hepatic arterial blood flow with NP, neither ATP nor NP significantly altered blood flow to the brain, spinal cord, spleen, kidney, jejunum, muscle, and skin. Controlled hypotension by ATP was stable and rapidly reversible without rebound hypertension. The results of this study indicate that ATP is a rapidly acting, effective hypotensive agent that compares favorably with NP.

Key Words: ANESTHETIC TECHNIQUES—hypotensive.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999