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Anesth Analg 1986; 65:191-192
© 1986 International Anesthesia Research Society
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Effect of Cimetidine on Duration of Action of Succinylcholine

J. Reddy Kambam, MD, Richard Dymond, MD, and Michael Krestow, MD

King Fahad Hospital, Riyadh, Saudi Arabia.

Abstract

Administration of cimetidine, an H2-receptor antagonist, is associated with a direct inhibition of liver microsomal enzymes and a decrease in liver blood flow resulting in a variety of clinically significant drug interactions (1,2). Cimetidine is one of the more frequently prescribed drugs in the United States and a large number of these patients who are taking cimetidine are coming to the operating room today. The effects of cimetidine on the action of muscle relaxants have not been reported. The purpose of the present study is to investigate the effects of cimetidine on the onset and duration of action of succinylcholine.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.