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Anesth Analg 1986; 65:252-258
© 1986 International Anesthesia Research Society
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Effects of Dantrolene and Verapamil on Atrioventricular Conduction and Cardiovascular Performance in Dogs

Carl Lynch, III, MD, PhD, Charles G. Durbin, Jr, MD, Nancy A. Fisher, PhD, MD, Robert A. Veselis, MD, and John S. Althaus, MS

Department of Anesthesiology, University of Virginia Medical Center, Charlottesville, Virginia.

Abstract

The effects of intravenous dantrolene sodium, alone and in combination with verapamil, upon atrioventricular conduction, cardiovascular function, and neuromuscular function were studied in chloralose-urethane anesthetized dogs. Hemodynamic variables (systemic arterial, central venous, and pulmonary arterial pressures and cardiac output) and His-bundle electrograms were monitored, and measurements were made during atrial pacing at 175 beats/min, as well as at the spontaneous heart rate. In one part of the study animals received dantrolene sodium incrementally at 30-min intervals to cumulative doses of 1, 2.5, 5, and 10 mg/kg. Subsequently, verapamil was administered incrementally at 30-min intervals to cumulative doses of 0.1, 0.2, 0.4, and 0.6 mg/kg. In the second part of the study, dogs received identical dosage sequences, but verapamil preceded dantrolene administration. Dantrolene caused no significant depression of atrioventricular conduction or cardiac performance but did increase systemic vascular resistance at doses above 2.5 mg/kg. Verapamil alone (≥ 0.2 mg/kg) or with dantrolene (≥ 0.1 mg/kg) increased the atrial-His-bundle conduction interval. In the presence of verapamil, dantrolene (≥ 2.5 mg/kg) decreased cardiac index and increased pulmonary artery occlusion pressure. Although 0.6 mg/kg uprapamil depressed cardiac index and increased pulmonary artery occlusion pressure, this effect was observed at 0.4 mg/kg after prior treatment with dantrolene. Verapamil did not augment the dose-dependent twitch depression observed with dantrolene. Dantrolene alone had no apparent effect on atrioventricular conduction and caused little enhancement of the effects of verapamil. However, each drug appeared to enhance the myocardial depressarrt effects of the other.

Key Words: PHARMACOLOGY—verapamil, dantrolene • HEART—atrioventricular, conduction, myocardial function • NEUROMUSCULAR RELAXANTS—dantrolene




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S. Cho, S. Zhang, H. Ureshino, T. Hara, S. Tomiyasu, and K. Sumikawa
Hemodynamic Interactions of Propofol and Dantrolene in Chronically Instrumented Dogs
Anesth. Analg., May 1, 2003; 96(5): 1369 - 1373.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.