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Double-Blind Comparison of Intravenous Doses of Dezocine, Butorphanol, and Placebo for Relief of Postoperative Pain

Department of Anesthesiology, Denver General Hospital, Denver, Colorado.

Abstract

The safety and efficacy of intravenous doses of dezocine (5 or 10 mg), butorphanol (1 mg), and placebo were compared in a double-blind study in 160 patients with moderate to severe postoperative pain. Analgesic efficacy was assessed for 6 hours after each dose. Mean pain relief scores were consistently higher, indicating greater pain relief, for the three active treatment groups than for the placebo group. The 10-mg dezocine dose was the most effective treatment, and 5 mg of dezocine was comparable to 1 mg of butorphanol. In the 2 hours after the first dose, 32% of the 10-mg dezocine group, 53% of the 5-mg dezocine group, 65% of the butorphanol group, and 88% of the placebo group withdrew from the study because of unsatisfactory pain relief. The differences in these percentages were statistically significant (P < 0.05) between each active therapy group and the placebo group, arid between the 10-mg dezocine group and the butorphanol group. Changes in degree of sedation were similar in the three active therapy group. Adverse reactions were rare, mild, and equally distributed among the four treatment groups. We conclude that 10 mg of dezocine is Superior to 1 mg of butorphanol, arid that 5 mg of dezocine, is as effective as 1 mg of butorphanol for the relief of moderate to severe postoperative pain.

Key Words: ANALGESICS—dezocine • PAIN—postoperative

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999