JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 1986; 65:337-340
© 1986 International Anesthesia Research Society
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lake, C. L.
Right arrow Articles by Crampton, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lake, C. L.
Right arrow Articles by Crampton, R. S.

Lidocaine Enhances Intraoperative Ventricular Defibrillation

Carol L. Lake, MD, Irving L. Kron, MD, Robert M. Mentzer, MD, and Richard S. Crampton, MD

Received from the Departments of Anesthesiology, Internal Medicine (Cardiology), and Surgery (Thoracic and Cardiovascular), University of Virginia Medical Center, Charlottesville, Virginia.

Abstract

The efficacy of lidocaine during myocardial reperfusion in coronary artery bypass surgery was evaluated in 20 patients randomly assigned to a control group (n = 10) or to receive lidocaine, 1 mg/kg intravenously 5 min before aortic unclamping and cardiac reperfusion, followed by infusion at 40 µg·kg–1 ·min–1 (n = 10). We recorded ECG leads II and V5 continuously, and number, energy, and current of direct current (DC) shocks starting at 1 joule. The number of low energy DC shocks to sustained defibrillation (5.5 ± 2.0 vs 3.5 ± 2.0, mean ± SD, P < 0.05) decreased significantly with lidocaine infusion. The energy (11.0 ± 6.3 vs 5.6 ± 3.9 joules, P < 0.05) and current (12.7 ± 4.2 vs 8.9 ± 4.7 amperes, not significant) likewise decreased with lidocaine infusion. Energy and current for the first successful shock, although lower in the lidocaine group, were not statistically significantly lower than in the control group. Initial reperfusion rhythm was not influenced by lidocaine. Plasma electrolyte levels, arterial blood gas tensions, myocardial temperature, and surgical technique—factors known to influence defibrillation—were similar in all patients. Administration of lidocaine during myocardial reperfusion allows defibrillation with fewer DC shocks of lower energy and current.

Key Words: HEART, ARRHYTHMIAS—defibrillation • ANESTHESIA—cardiovascular • ANESTHETICS, LOCAL—lidocaine




This article has been cited by other articles:


Home page
 HeartHome page
A A J Adgey and P W Johnston
Approaches to modern management of cardiac arrest
Heart, October 1, 1998; 80(4): 397 - 401.
[Full Text]

Home page
 BMJHome page
Advanced Life Support Working Group of the Europea
The 1998 European Resuscitation Council guidelines for adult advanced life support
BMJ, June 20, 1998; 316(7148): 1863 - 1869.
[Full Text]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.