JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kasten, G. W. Articles by Martin, S. T. Search for Related Content PubMed PubMed Citation Articles by Kasten, G. W. Articles by Martin, S. T.

Resuscitation from Bupivacaine-Induced Cardiovascular Toxicity During Partial Inferior Vena Cava Occlusion

Received from the Department of Anesthesiology, University of Kentucky A. B. Chandler Medical Center, and the Veterans Administration Medical Center, Lexington, Kentucky.

Abstract

The hemodynamic effects and ability to resuscitate animals experiencing bupivacaine cardiovascular toxicity after partial inferior venu cava occlusion were investigated in anesthetized dogs (n = 12). Partial occlusion of the inferior vena cava resulted in a 12% decrease in mean arterial pressure, a 62% decrease in cardiac output, a 66% decrease in stroke volume, and a 135% increase in systemic vascular resistance. Bupivacaine, 20 mg/kg intravenously, resulted in cardiovascular collapse in all animals. The resuscitation time for animals without partial caval occlusion was 2.1 ± 0.5 min, whereas that for animals with partial caval occlusion was 22.2 ± 6.9 min (P < 0.05). Significantly increased amounts of epinephrine and NaHCO₃ were required to resuscitate the animals with caval occlusion. We conclude that partial inferior vena cava occlusion can significantly alter the ability to resuscitate animals experiencing bupivacaine cardiovascular toxicity.

Key Words: ANESTHETICS, LOCAL—bupivacaine • ANESTHESIA—obstetric • TOXICITY—bupivacaine

This article has been cited by other articles:

				D. J McAuley Trauma in pregnancy: anatomical and physiological considerations Trauma, October 1, 2004; 6(4): 293 - 300. [Abstract] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999