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Anesth Analg 1986; 65:350-354
© 1986 International Anesthesia Research Society
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Selective Kappa Opioid Agonist for Spinal Analgesia without the Risk of Respiratory Depression

Raul Castillo, MD, Igor Kissin, MD, PhD, and Edwin L. Bradley, PhD

Received from the Pain Research Center, Department of Anesthesiology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.

Abstract

The effects of the selective {kappa} agonist, U-50,488H, on the motor response to noxious mechanical stimulation when administered intrathecally, as well as on respiratory rate and Paco2 when administered by intracerebroventricular injection, were compared with those of morphine in experiments on rats. The agonist U-50,488H caused a dose-dependent increase in the threshold to noxious stimulation but did not have a potential for depression of resting ventilation. The results suggest that selective {kappa} opioid agonists may be suitable for clinical spinal (epidural) analgesia without the associated risk of respiratory depression.

Key Words: ANESTHETIC TECHNIQUES—spinal • ANALGESICS—opioid




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.