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Succinylcholine Pretreatment with Magnesium Sulfate

Received from the Department of Anaesthetics, University of the Witwatersrand and Hillbrow Hospital, Johannesburg, South Africa, and the Department of Anesthesiology, University of Arizona, Tucson, Arizona.

Abstract

The effect of pretreatment with 60 mg/kg magnesium sulfate on the neuromuscular blockade and consequent potassium release produced by 1.5 mg/kg succinylcholine in ten normal patients was compared with ten saline pretreated control patients. Magnesium had no significant effect on the characteristics of the paralysis. In control patients, serum potassium increased by an average of 0.57 ± 0.20 (SEM) mmol/L. No patient in the magnesium group had an increase in serum potassium (mean change –0.05 ± 0.02 mmol/L). The difference between the groups was statistically significant (P < 0.01).

Key Words: IONS—magnesium, potassium • NEUROMUSCULAR RELAXANTS—succinylcholine

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999