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Anesth Analg 1986; 65:385-388
© 1986 International Anesthesia Research Society
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Comparison of Oral Controlled Release Morphine and Epidural Morphine in the Management of Postoperative Pain

Anne-Marie Banning, MD, Jes Frederik Schmidt, MD, Bent Chræmmer-Jørgensen, MD, and Allan Risbo, MD

Received from the Department of Anesthesia, University of Copenhagen, Glostrup Hospital, Glosrrup, Denmark.

Abstract

Oral controlled release morphine (CRM) was compared in a double-blind study with epidural morphine (EM) for postoperative pain relief in 20 patients undergoing knee arthrotomy under epidural anesthesia. Ten patients received 30 mg CRM orally and saline epidurally (CRM group), and ten patients received placebo tablets orally and 4 mg morphine epidurally (EM group), both at the time of skin incision and then every 8 hr for 48 hr during which patients evaluated pain intensity using a visual analog scale. Nine of the ten patients in the EM group had good relief of pain throughout the study period. Seven of the ten patients in the CRM group needed rescue analgesics within 6 hr of the initiation of the study (P < 0.01). We conclude that CRM is not suitable for the control of early postoperative pain, whereas epidural morphine is excellent.

Key Words: PAIN—postoperative • ANALGESICS—morphine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.