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Anesth Analg 1986; 65:392-394
© 1986 International Anesthesia Research Society
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Neonatal Responses to Alphaprodine Administered during Labor

Kazusighe Murakawa, MD, Therese K. Abboud, MD, and Thormason Yanagi, MD

Received from the Department of Anesthesiology, Los Angeles County-University of Southern California Medical Center, Los Angeles, California.

Abstract

The effect of intravenously administered alphaprodine on newborn Apgar scores, neonatal acid-base status, and the Neurologic and Adaptive Capacity Scoring System (NACS) were compared in 30 parturients. Patients in group 1 (n = 15) received 20–40 mg increments of alphaprodine, with a total dose of 39.3 ± 3.7 mg (Formula ± SEM). Group 2 patients (n = 15) received no medication during labor. Apgar scores, neonatal acid-base status, and the NACS were equally good in the two groups. The concentrations of alphaprodine in maternal vein, umbilical vein, and umbilical artery at delivery were measured using a gas-chromographic mass spectrophotometric technique. The results showed an umbilical vein-to-maternal vein ratio of 0.52 ± 0.09. It is concluded that when administered as in this study, alphaprodine has no adverse effects on the neonate.

Key Words: ANESTHESIA—obstetric • ANALGESICS—alphaprodine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.