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Naloxone Attenuates Hypoxic Depression of Ganglionic Transmission

Received from the Department of Anesthesiology, Niigata University School of Medicine, Niigata, and the Department of Physiology, Kurume University School of Medicine, Kurume, Japan.

Abstract

The effect of the opioid antagonist naloxone on hypoxia-induced blockade of synaptic transmission in the superior cervical ganglion (SCG) of the rat was studied in vitro. Naloxone (6 x 10 ^–6M or more) attenuated the hypoxia-induced blockade of synaptic transmission in the SCG. In addition, in the concentrations studied, naloxone itself had a blocking effect on ganglionic transmission that involved terminal sites of the preganglionic axons. These data suggest that the protective effect of higher doses of naloxone on the hemodynamic responses to hypoxemia or ischemia may originate at least in part from the attenuating effect of naloxone on the hypoxia-induced blockade of ganglionic transmission.

Key Words: HYPOXIA, GANGLIONIC TRANSMISSION—naloxone • ANTAGONISTS, NARCOTIC—naloxone

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999