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Anesth Analg 1986; 65:493-495
© 1986 International Anesthesia Research Society
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Tubocurarine Sensitivity of the Diaphragm after Limb Immobilization

Barbara E. Waud, MD, and Douglas R. Waud, MD, D Phil

Received from the Departments of Anesthesiology and Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts.

Abstract

The effect of immobilization of a limb on subsequent sensitivity of the diaphragm to d-tubocurarine was examined in the guinea pig. A forelimb was immobilized in a plaster cast for 1 or 3 weeks. An isolated nerve-diaphragm preparation was then set up and the sensitivity to d-tubocurarine measured. Parallel assays on a nerve-lumbrical muscle preparation from the limb in the cast were also examined for comparison. The diaphragm from unimmobilized animals showed the normal decreased sensitivity relative to the lumbrical. After immobilization the sensitivity of the lumbrical decreased, whereas that of the diaphragm did not change. Thus in contrast to previously observed behavior in limb muscles, changes in d-tubocurarine sensitivity produced by immobilization do not involve the diaphragm.

Key Words: NEUROMUSCULAR RELAXANTS—d-tubocurarine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.