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Anesth Analg 1986; 65:503-506
© 1986 International Anesthesia Research Society
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Rapid Sequence Induction Using Vecuronium

Vimala E. Kunjappan, MD, Eli M. Brown, MD, and Gay lord D. Alexander, MD

Received from the Department of Anesthesiology, Sinai Hospital of Detroit, Detroit, Michigan.

Abstract

The purpose of this study was to determine the ideal priming and total dose of vecuronium when used as the relaxant during rapid sequence induction of anesthesia and tracheal intubation. Seventy patients were studied. Various priming and total dose schedules using vecuronium were compared with succinylcholine, 1.5 mg/kg. The mean onset times, intubating conditions, and mean duration times were compared. A priming dose of 10 µg/kg produced good intubation conditions with both 70 µg/kg and 150 µg/kg (total doses), but the mean onset times remained significantly longer than succinylcholine 1.5 mg/kg (P < 0.05). A priming dose of 15 µg/kg of vecuronium with 100 µg/kg total dose, on the other hand, not only produced excellent intubating conditions but also resulted in a mean onset time not significantly different from succinylcholine, 1.5 mg/kg. This latter dose schedule of vecuronium is recommended for rapid sequence induction when succinylcholine is contraindicated. Vecuronium is preferable to pancuronium for rapid sequence induction because of its lack of cardiovascular side effects and short duration.

Key Words: NEUROMUSCULAR RELAXANTS—vecuronium • INDUCTION, ANESTHESIA—rapid sequence






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.