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Anesth Analg 1986; 65:511-515
© 1986 International Anesthesia Research Society
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Evaluation of Lidocaine as an Adjunct to Fentanyl Anesthesia for Coronary Artery Bypass Graft Surgery

Gregory W. Kasten, MD, and Eddie Owens, MD

Received from the Department of Anesthesiology, University of Kentucky A.B. Chandler Medical Center and Veterans Administration Medical Center, Lexington, Kentucky.

Abstract

A double-blind, randomized, prospective trial was conducted to evaluate intravenous lidocaine, 3 mg/kg, followed by an infusion of 0.05 mg·kg–1·min–1, as an adjunct to fentanyl in 20 patients undergoing coronary artery bypass graft surgery. Lidocaine prevented hemodynamic abnormalities during tracheal intubation and after skin incision, but was ineffective in preventing hypertension following sternotomy. Intravenous lidocaine, 3 mg/kg, produced a decrease in mean arterial pressure after fentanyl, 30 that was unacceptable in some patients. Total fentanyl requirements for the duration of surgery were similar in the control group and in patients given lidocaine. We conclude that lidocaine, when administered as an adjunct to fentanyl in the dosage used in this study, can cause cardiovascular depression, and is of minimal benefit in preventing hemodynamic abnormalities after sternotomy during coronary artery bypass graft surgery.

Key Words: ANESTHETICS, LOCAL—lidocaine • ANESTHESIA—cardiovascular






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.