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The Effects of Midazolam on Cerebral Blood Flow and Oxygen Consumption and Its Interaction with Nitrous Oxide

Department of Anesthesiology, Michael Reese Hospital and Medical Center, Chicago, Illinois.

Abstract

The effects of the intravenous infusion of midazolam on cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO₂) were measured in rats in the presence and absence of nitrous oxide. Midazolam produced 40–45% decreases in CBF with no difference in response between nitrous oxide and nitrogen-ventilated rats. CMRO₂ decreased 55% during midazolam infusion in rats ventilated with nitrogen, significantly more (P < 0.05) than in rats ventilated with nitrous oxide (35%). We conclude that cerebrovascular responses to midazolam infusion were not altered by nitrous oxide and suggest that nitrous oxide may slightly but significantly stimulate brain metabolism during midazolam infusion.

Key Words: HYPNOTICS, BENZODIAZEPINES—midazolam • ANESTHETICS, GASES—nitrous oxide • BRAIN—blood flow, metabolism

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999