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Anesth Analg 1986; 65:734-738
© 1986 International Anesthesia Research Society
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Transperitoneal Oxygenation with Fluorocarbons

Jan Klein, MD, N. Simon Faithfull, MB, PhD, FFARCS, Patrick J. Salt, MA, MB, PhD, FFARCS, and Adrianus Trouwborst, MD, PhD

Department of Anaesthesia, Erasmus University, Rotterdam, The Netherlands, and the Department of Anaesthesia, University of Birmingham, United Kingdom.

Abstract

This work investigated the improvement of arterial oxygenation in hypoxic rats during peritoneal perfusion with the oxygen-carrying perfluorocarbon blood substitute FC43. Three groups of six Wistar rats were ventilated with hypoxic gas mixtures to obtain an arterial oxygen tension (PaO2) of approximately 55 mm Hg. Two groups were subjected to peritoneal perfusion at 20 mllmin with oxygenated FC43or the gelatine solution Haemaccel. A third group was sham operated but not perfused. In both perfused groups PaO2 increased significantly, more so in the FC43 group. Carbon dioxide tensions significantly decreased only in the FC43 group. Significant increases in arterial oxyhemoglobin saturation were seen after 15 min in the FC43 group and after 60 min in the Haemaccel group. More than 15% of oxygen consumption could be delivered by peritoneal perfusion with FC43.

Key Words: PHARMACOLOGY—fluorocarbons




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S. R. Carr, J. P. Cantor, A. S. Rao, T. V. Lakshman, J. E. Collins, and J. S. Friedberg
Peritoneal perfusion with oxygenated perfluorocarbon augments systemic oxygenation.
Chest, August 1, 2006; 130(2): 402 - 411.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.