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Anesth Analg 1986; 65:743-746
© 1986 International Anesthesia Research Society
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Pharmacokinetics and Pharmacodynamics of Atracurium during Isoflurane Anesthesia in Normal and Anephric Patients

Frederic M. deBros, MD, A. Lai, PhD, R. Scott, MD, J. deBros, RNA, A. G. Batson, BS, N. Goudsouzian, MD, H. H. Ali, MD, A. B. Cosimi, MD, and J. J. Savarese, MD

Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts.

Abstract

We compared the pharmacokinetics and pharmacodynamics of atracurium in eight normal and eight anephric patients during isoflurane anesthesia. Plasma concentrations were measured by high performance liquid chromatography after a single injection of 0.5 mg/kg, and neuromuscular effects were evaluated by the single twitch method. With regard to pharmacokinetic or pharmacodynamic parameters, we found no statistically significant differences between normal and anephric patients. We conclude that during isoflurane anesthesia, anephric patients distribute and eliminate atracurium much as normal patients do.

Key Words: NEUROMUSCULAR RELAXANTS—atracurium • PHARMACOKINETICS—atracurium • ANESTHETICS, VOLATILE—isoflurane • KIDNEY—failure






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1986 by the International Anesthesia Research Society.