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A Randomized Comparison Between Midazolam and Thiopental for Elective Cesarean Section Anesthesia

II. Neonates

Department of Anesthesiology, Esbjerg Central Hospital, Esbjerg, Denmark and the Department of International Clinical Research, F. Hoffman-La Roche & Co., Ltd., Hvidovre, Denmark.

Abstract

In a randomized blind trial, the general condition of 40 neonates was assessed following midazolam- or thiopental-based general anesthesia for elective cesarean section. Among 19 neonatal neurobehavioral observations and tests, statistically significant differences between the midazolam and the thiopental groups were rare. However, a statistically significant interaction with regard to body temperature, general body tone, and arm recoil was observed where results were inferior for midazolam, although only within the first 2 hours.

It was concluded that midazolam is as safe as thiopental for the induction and maintenance of elective cesarean section anesthesia in neonates.

Key Words: ANESTHESIA, obstetrical • ANESTHETICS, INTRAVENOUS—midazolam, thiopental • HYPNOTICS, BENZODIAZEPINES— midazolam

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