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Anesth Analg 1989; 68:462-466
© 1989 International Anesthesia Research Society
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The Effect of Sublingual Nifedipine on Coronary Venous Graft Resistance Immediately Following Cardiopulmonary Bypass

Thomas R. Eide, MD, Robert I. Katz, MD, and Paul J. Poppers, MD

Department of Anesthesiology, University Hospital at Stony Brook, State University of New York at Stony Brook, Stony Brook, New York.

Abstract

The purpose of this study was to determine the effects of sublingual nifedipine administered immediately after discontinuation of cardiopulmonary bypass on coronary graft resistance and systemic hemodynamics. Twenty patients were prospectively randomized into two groups; one given 10 mg sublingal nifedipine after weaning from bypass, the other given a placebo. Coronary graft blood flow was measured under blinded conditions and graft resistance calculated from measurements obtained with an electromagnetic flow probe applied directly to the graft prior to and 15 minutes after drug administration. Serum nifedipine levels were determined immediately before and 15, 30, and 60 minutes after sublingal administration. All patients receiving nifedipine had therapeutic serum levels. Graft resistance in patients given nifedipine decreased a statistically significant average of 27% and increased slightly, but not statistically significantly so, in patients given sublingual placebos. There were no differences between the two groups in cardiac index or pulmonary capillary wedge pressures. We conclude that the administration of sublingual nifedipine to patients in the immediate postbypass period results in therapeutic serum nifedipine levels and decreases coronary graft resistance without affecting cardiac performance.

Key Words: ANESTHETICS, intravenous: sufentanil • ANESTHESIA—cardiovascular • HEART—nifedipine
Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1989 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1989 by the International Anesthesia Research Society.