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Anesth Analg 1989; 68:506-510
© 1989 International Anesthesia Research Society
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Effect on Airway Resistance of Ketamine by Aerosol In Guinea Pigs

Michael J. Rock, MD, Santiago Reyes de la Rocha, MD, Megan Lerner, Daniel Brackett, and Michael F. Wilson, MD

Department of Pediatrics, Section of Pulmonary Diseases, University of Oklahoma Medical Center, Oklahoma City, Oklahoma.

Abstract

The effect of aerosolized ketamine hydrochloride was investigated by measuring airway resistance with a two-compartment plethysmography in guinea pigs challenged with histamine. In the first phase of the study, treatment with ketamine prior to histamine challenge did not protect against elevation of airway resistance. In the second phase of the study, ketamine inhalation after histamine challenge did not significantly diminish airway resistance. Aerosolized ketamine is not recommended for use in human subjects with asthma.

Key Words: ANESTHETICS, INTRAVENOUS—ketamine • LUNGS, bronchi
Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1989 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1989 by the International Anesthesia Research Society.