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Azumolene Reverses Episodes of Malignant Hyperthermia in Susceptible Swine

Received from the Department of Anaesthesia, Massachusetts General Hospital and Harvard Medical School, and Department of Muscle Research, Boston Biomedical Research Institute, Boston, Massachusetts.

Abstract

Azumolene is an analogue of dantrolene with much greater water solubility. Ten swine susceptible to malignant hyperthermia (MH) were triggered into MH episodes via the inhalation of halothane, and azumolene was effective in terminating all of the MH episodes. There was an inverse relationship between the dose of azumolene required to terminate the MH episode and the time it took for the pig to manifest the signs of MH. Azumolene was found to be similar in potency to dantrolene.

Key Words: HYPERTHERMIA, MALIGNANT—azumolene, dantrolene

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