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Anesth Analg 1990; 70:428-432
© 1990 International Anesthesia Research Society
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Effect of Combined Infusion of Nitroglycerin and Nicardipine on Femoral-to-Radial Arterial Pressure Gradient After Cardiopulmonary Bypass

Kazuo Maruyama, MD, Ryoji Horiguchi, MD, Hiroshi Hashimoto, MD, Yumiko Ohi, MD, Masahiro Okuda, MD, Takaaki Kurioka, MD, Kunihiko Konishi, MD, Mannosuke Muneyuki, MD, and Minoru Kusagawa, MD

Departments of Anesthesiology, and Thoracic and Cardiovascular Surgery, and the Intensive Care Unit, Mie University School of Medicine, Mie, japan; and the Department of Anesthesia, Matsusaka Central General Hospital, Urata, Mat-susaka, Mie, Japan.

Abstract

Nitrates and calcium channel blockers are frequently administered during cardiac surgery. We simultaneously measured femoral arterial pressure and radial arterial pressure to investigate whether nitrates, in conjunction with calcium channel blockers, would influence the central-to-peripheral arterial pressure gradient. Combined nitroglycerin and nicardipine infusion during cardiac surgery involving coronary artery bypass grafting or valve replacement resulted in a significant increase above baseline levels in the femoral-to-radial arterial pressure gradient at 60 min after Cardiopulmonary bypass. In control patients there was no significant increase in the femoral-to-radial arterial pressure gradient at 60 min after completion of Cardiopulmonary bypass. A subsequent study in patients given nitroglycerin and nicardipine identified that the difference in the systolic arterial pressure between femoral and radial arteries was observed 15, 60, and 120 min after completion of cardio-pulmonary bypass. However, there was no difference in the mean arterial pressure between femoral and radial arteries throughout the same period. We conclude that combined infusion of nitroglycerin and nicardipine, a new calcium channel blocker, intensifies the magnitude and duration of the femoral-to-radial arterial pressure gradient after cardio-pulmonary bypass.

Key Words: ANESTHESIA, CARDIOVASCULAR—arterial pressures. • BLOOD PRESSURE MONITORING, CARDIOPULMONARY BYPASS.
Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1990 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1990 by the International Anesthesia Research Society.