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Anesth Analg 1990; 70:493-498
© 1990 International Anesthesia Research Society
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Effect of Nifedipine on Morphine-Induced Analgesia

Franco Carta, MD, Mauro Bianchi, MD, Stefano Argenton, MD, Daniele Cervi, MD, Giampaolo Marolla, MD, Maria Tamburini, MD, Massimo Breda, PhD, Antonio Fantoni, MD, and Alberto E. Panerai, MD

Department of Anesthesiology and Resuscitation, Ospedale S. Carlo Borromeo, Milan, and the Department of Pharmacology, University of Milan, Milan, Italy.

Abstract

Experimental data show that opiates interfere with calcium influx in the cell and that some calcium-channel blockers are analgesic. We therefore studied the effect of the calcium-receptor blocker nifedipine on the analgesic effect of morphine in the rat, using tail-flick responses, and in humans, using measurements of the intensity of postoperative pain. In both the experimental animals and humans nifedipine significantly (P < 0.001) increased the analgesic effect of morphine independently of any effect on the metabolism of morphine. Respiratory and cardiovascular functions were not significantly changed by nifedipine. The data indicate that Ca2+ is important in mediating the analgesic effects of opiates and suggest that calcium-receptor blockers might find a place in the treatment of pain.

Key Words: ANALGESICS, MORPHINE • PHARMACOLOGY, CALCIUM-CHANNEL BLOCKERS—nifedipine • PAIN, POSTOPERATIVE




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1990 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1990 by the International Anesthesia Research Society.