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Anesth Analg 1990; 70:499-506
© 1990 International Anesthesia Research Society
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Inotropic Effect of Meperidine

Influence of Receptor and Ion Channel Blockers in the Rat Atrium

Knut G. Helgesen, MD, Øyvind Ellingsen, MD, Dr.Med, and Arnfinn Ilebekk, MD, Dr.Med

Institute for Experimental Medical Research, Ullevål Hospital, and the Department of Anesthesiology, University of Oslo, Oslo, Norway.

Abstract

Meperidine increases developed force in isolated rat atria. We initiated this study to determine if this positive inotropic effect was attenuated by commonly used receptor-and ion channel blockers. Neither naloxone (opioid blocker), phentolamine (ß-adrenoceptor blocker), propranolol ({alpha}-adrenoceptor blacker), polaramine (H1-receptor blocker), ranitidine (H2-receptor blocker), verapamil (calcium-channel blocker), nor lidocaine (fast sodium-channel blocker) attenuated the positive inotropic effect of meperidine. However, after lidocaine pretreatment meperidine increased contractile force by 57% (27%--80%) (median and 95% confidence interval), which is significantly more (P < 0.001) than the 21% (13%--35%) increase seen after pretreatment with saline. After Na, K-pump inhibition by ouabain, meperidine caused no further increase in contractility, but the atria still responded to isoproterenol with an increase in developed force. Conversely, meperidine prevented the positive inotropic effect of ouabain. These findings suggest that the positive inotropic effect of meperidine is mediated by an increase in intracellular sodium activity and not by regulation of the slow inward calcium channel.

Key Words: ANALGESICS, MEPERIDINE • HEART, CONTRACTILITY—meperidine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1990 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1990 by the International Anesthesia Research Society.