JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

Anesth Analg 1990; 70:530-536
© 1990 International Anesthesia Research Society
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kobayashi, Y.
Right arrow Articles by Okabe, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kobayashi, Y.
Right arrow Articles by Okabe, E.

Effect of Enflurane on Contractile Reactivity in Isolated Canine Mesenteric Arteries and Veins

Yutaka Kobayashi, DDS, PhD, Kazu-ichi Yoshida, DDS, Masahiro Noguchi, MD, PhD, Yoshifumi Wakasugi, DDS, Haruo Ito, MD, PhD, and Eiichiro Okabe, DDS, PhD

Departments of Anesthesiology and Pharmacology, Kanagawa Dental College, 82 Inaoka-Cho, Yokosuka, Kanagawa 238, Japan.

Abstract

The effects of enflurane on responses of isolated canine mesenteric arteries and veins to transmural nerve stimulation and to exogenously administered norepinephrine (a mixed {alpha}1-and {alpha}2-adrenoceptor agonist), phenylephrine (a selective {alpha}1-adrenoceptor agonist), and tyramine were studied. The contractile responses of the arteries and the veins to transmural nerve stimulation and to norepinephrine were attenuated by exposure to enflurane; the responses to phenylephrine were decreased more than those to norepinephrine. When compared with the effect of enflurane on transmural nerve stimulation-induced responses, exposure to enflurane resulted in slight attenuation of the contractile responses caused by tyramine, suggesting that enflurane may inhibit the responses to tyramine by interfering with an interaction between released norepinephrine and postjunctional {alpha}1-adrenoceptors rather than with tyramine-induced norepinephrine release. The data are also consistent with the view that enflurane acts on sympathetic nerve endings to inhibit release of norepinephrine associated with electrical stimulation-induced nerve membrane depolarization.

Key Words: ANESTHETICS, VOLATILE—enflurane • MUSCLE, SMOOTH—vascular • ARTERIES, ENFLURANE EFFECTS • VEINS, ENFLURANE EFFECTS




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
B. Kabon, E. Fleischmann, T. Treschan, A. Taguchi, S. Kapral, and A. Kurz
Thoracic Epidural Anesthesia Increases Tissue Oxygenation During Major Abdominal Surgery
Anesth. Analg., December 1, 2003; 97(6): 1812 - 1817.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
T. A. Treschan, A. Taguchi, S. Z. Ali, N. Sharma, B. Kabon, D. I. Sessler, and A. Kurz
The Effects of Epidural and General Anesthesia on Tissue Oxygenation
Anesth. Analg., June 1, 2003; 96(6): 1553 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
S. R. Arain, D. J. Williams, B. J. Robinson, T. D. Uhrich, and T. J. Ebert
Vascular Responsiveness to Brachial Artery Infusions of Phenylephrine During Isoflurane and Desflurane Anesthesia
Anesth. Analg., May 1, 2002; 94(5): 1137 - 1140.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1990 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1990 by the International Anesthesia Research Society.