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Anesth Analg 1990; 70:577-582
© 1990 International Anesthesia Research Society
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Cardiovascular Effects and Regional Clearances of Intravenous Ropivacaine in Sheep

Albert J. Rutten, BSc, Laurence E. Mather, PhD, FFARACS, Craig Nancarrow, FFARACS, PhD, Paul A. Sloan, MD, FRCP(C), and Colin F. McLean, Dip Chem

Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, South Australia, Australia.

Abstract

The purpose of this study was to determine the cardiovascular effects and the total body and regional clearances of ropivacaine during its continuous intravenous infusion to subtoxic levels in five conscious unrestrained sheep that had been previously prepared with appropriate intravascular cannulas. Ropivacaine HCl·H2O, 1 mg/min, produced constant arterial blood concentrations which ranged from 0.70 to 1.84 mg/L. This caused no appreciable cardiovascular effects. The mean total body clearance (± SD) of ropivacaine was 1.00 ± 0.27 L/min. There was significant clearance of ropivacaine by the liver (0.85 ± 0.32 L/min), gut (0.09 ± 0.07 L/min), and kidneys (0.04 ± 0.03 L/min). There was no significant clearance of ropivacaine by the lungs, brain, heart, or hindquarters. It was concluded that the liver accounts for the majority of ropivacaine clearance.

Key Words: ANESTHETICS, LOCAL—ropivacaine • PHARMACOKINETICS, ropivacaine




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1990 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1990 by the International Anesthesia Research Society.