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Rectal Methohexital

Concentration and Length of the Rectal Catheters

Department of Anesthesiology and Pathology, University of Texas Medical School at Houston, Houston, Texas.

Abstract

In the study, the authors evaluated the concentration of rectal methohexital (1% vs 10%) and the length of the rectal catheter (3.8 vs 12.7 cm), on sleep-success rate, administration-sleep time, methohexital plasma concentrations, and recovery time in 85 healthy children scheduled for elective ophthalmic or ear, nose, or throat operations lasting approximately 1 h. At a dose of 25 mg/kg, the 1% solution of rectal methohexital was associated with a significant (P < 0.05) higher sleep-success rate (95% vs 70%), shorter administration-sleep time (5.7 ± 1.9 vs 7.0 ± 2.0 min), higher methohexital plasma concentrations at 20 min (6.5 vs 4.7 ng/mL) and at 30 min (5.3 vs 3.7 ng/mL), and prolonged recovery time (53.2 ± 31.1 vs 32.4 ± 18.5 min). The length of the rectal catheters did not significantly affect sleep-success rate, administration-sleep time, methohexital plasma concentrations, or recovery time. The use of 25 mg/kg of 1% rectal methohexital solution to induce anesthesia in children is superior to the use of 25 mg/kg of 10% methohexital solution for induction of anesthesia in children, particularly in operations 1 h or longer in duration.

Key Words: ANESTHETIC TECHNIQUES, RECTAL—methohexital • ANESTHETICS, RECTAL—methohexital

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