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Anesth Analg 1990; 71:70-72
© 1990 International Anesthesia Research Society
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Absence of Abundant Saturable Binding Sites for Halothane or Isoflurane in Rabbit Brain

Inhaled Anesthetics Obey Henry's Law

Stephen H. Lockhart, PhD, and Edmond I. Eger, II, MD

Received from the Department of Anesthesia, University of California, San Francisco, California.

Abstract

We tested whether the existence of saturable binding sites for anesthetics causes the solubility of halothane or isoflurane in rabbit brain not to obey Henry's law. For each anesthetic, we measured brain/gas partition coefficients (paired samples) at approximately 0.05 MAC and 5 MAC at 38.5°C. In addition, for halothane, brain/gas partition coefficients (paired samples) were determined at 0.05 MAC and 2 MAC. The values for halothane at 0.05 MAC, 2 MAC, and 5 MAC did not differ; values for isoflurane at 0.05 MAC and 5 MAC did not differ. Over the range of anesthetic partial pressures studied, no evidence for saturable binding was found. We conclude that the solubility of halothane and isoflurane in brain is independent of the partial pressure applied: inhaled anesthetics obey Henry's law.

Key Words: ANESTHETICS, VOLATILE—halothane, isoflurane. • SOLUBILITY—halothane, isoflurane. • PHYSICS—Henry's law.
Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1990 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1990 by the International Anesthesia Research Society.