This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Alon, E. Articles by Himmelseher, S. Search for Related Content PubMed PubMed Citation Articles by Alon, E. Articles by Himmelseher, S.

Ondansetron in the Treatment of Postoperative Vomiting

A Randomized, Double-Blind Comparison With Droperidol and Metoclopramide

Department of Anesthesiology, University Hospital, Zurich, Switzerland

The prophylactic antiemetic efficacy of ondansetron was evaluated in a randomized, double-blind comparison with droperidol and metoclopramide in 66 patients undergoing general anesthesia for dilatation and curettage. Ten minutes before induction of anesthesia, 22 patients received a single intravenous dose of 8 mg of ondansetron, 22 others received 1.25 mg of droperidol, and the remaining 22 received 10 mg of metoclopramide. Anesthesia was induced with 3.3–5 mg/kg of intravenous thiopental and maintained with 65% nitrous oxide in oxygen and 2%-3% enflurane. Postoperatively, the incidence of vomiting was 13% with ondansetron, 45% with droperidol, and 54% with metoclopramide (P < 0.05; overall x2 test). there was no statistically significant difference in the incidence of nausea among the groups. postoperative sedation and well-being scores were not significantly different among the groups. we conclude that preoperative prophylactic administration of ondansetron is superior to droperidol or metoclopramide in the prevention of emetic sequelae after general anesthesia for dilatation and curettage.

This article has been cited by other articles:

				E. P. Wilkens and B. J. Yates Pretreatment with Ondansetron Blunts Plasma Vasopressin Increases Associated with Morphine Administration in Ferrets Anesth. Analg., October 1, 2005; 101(4): 1029 - 1033. [Abstract] [Full Text] [PDF]

				K. B. Domino, E. A. Anderson, N. L. Polissar, and K. L. Posner Comparative Efficacy and Safety of Ondansetron, Droperidol, and Metoclopramide for Preventing Postoperative Nausea and Vomiting: A Meta-Analysis Anesth. Analg., June 1, 1999; 88(6): 1370 - 1370. [Abstract] [Full Text] [PDF]

				J. J. Chen, D. G. Frame, and T. J. White Efficacy of Ondansetron and Prochlorperazine for the Prevention of Postoperative Nausea and Vomiting After Total Hip Replacement or Total Knee Replacement Procedures: A Randomized, Double-blind, Comparative Trial Arch Intern Med, October 26, 1998; 158(19): 2124 - 2128. [Abstract] [Full Text] [PDF]

				M. R Tramèr, D J. M Reynolds, R A. Moore, and H. J McQuay When placebo controlled trials are essential and equivalence trials are inadequate BMJ, September 26, 1998; 317(7162): 875 - 880. [Full Text]

				R. L Aspinall and N. W Goodman Denial of effective treatment and poor quality of clinical information in placebo controlled trials of ondansetron for postoperative nausea and vomiting: a review of published trials BMJ, September 30, 1995; 311(7009): 844 - 846. [Abstract] [Full Text]

				P. G. Barash Anesthesiology JAMA, July 14, 1993; 270(2): 188 - 190. [Abstract] [PDF]