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Anesth Analg 1992; 75:708-714
© 1992 International Anesthesia Research Society
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A Comparison of the Effects of Propofol and Nitrous Oxide on the Electroencephalogram in Epileptic Patients During Conscious Sedation for Dental Procedures

Vivian L. B. Oei-Lim, MD, Cor J. Kalkman, MD, PhD, Elinor C.M. Bouvy-Berends, DDS, Eelco F. Posthumus Meyjes, MD, PhD, Peter C. Makkes, DDS, PhD, Doreen M. E. Vermeulen-Cranch, MD, FFARCS, Joseph A. Odoom, MD, PhD, Harry B. van Wezel, MD, PhD, and James G. Bovill, MD, PhD, FFARCSI

Departments of Anesthesiology and Clinical Neurophysiology, University of Amsterdam, Amsterdam; Department of Special Care Dentistry, Craeyenburch, Nootdorp; and Department of Anesthesiology, University of Leiden, Leiden, The Netherlands

The influence of sedative doses of propofol or nitrous oxide on the electroencephalogram was studied in 11 mentally handicapped patients with treated epilepsy undergoing dental procedures. At one session, propofol was titrated to achieve conscious sedation. The mean (±SD) dose requirements were 5.5 ± 1.1 mg.kg-1.h-1. In six patients, the electroencephalogram was unchanged during propofol administration. In three patients, there was a decrease in epileptic activity, and in two patients, paroxysmal discharges disappeared. At another session, nitrous oxide was administered by nasal mask. The mean (±SD) concentration of nitrous oxide needed was 43.6% ± 4.8%. The electroencephalogram did not change in nine patients, whereas in two patients epileptic activity decreased. There were no clinical epileptoid or other adverse manifestations during any treatment or up to 48 h thereafter. The results of the present study suggest that propofol or nitrous oxide can be administered in sub-anesthetic doses for conscious sedation in mentally handicapped patients with treated epilepsy.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1992 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1992 by the International Anesthesia Research Society.