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Anesth Analg 1992; 75:773-776
© 1992 International Anesthesia Research Society
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Lung Traction Causes an Increase in Plasma Prostacyclin Concentration and Decrease in Mean Arterial Blood Pressure

Mishiya Matsumoto, MD, Kenji Ohki, MD, Ikuo Nagai, MD, and Takao Oshibuchi, MD

Department of Anesthesiology, University of California at San Diego, La Jolla, California, and Division of Anesthesiology, Saiseikai Shimonoseki General Hospital, Yamaguchi, Japan

Abstract

The effects of lung traction on arterial blood pressure and plasma prostacyclin concentrations were studied in five patients undergoing partial pneumonectomy or lobectomy. After manual traction of a lung segment, mean arterial blood pressure decreased from 77 ± 5 mm Hg (mean ± SEM, before lung traction) to 59 ± 5 mm Hg. The concentrations of 6-keto prostaglandin F1a (a stable breakdown product of prostacyclin) increased significantly from 46 ± 6 pg/mL (mean ± SEM, before thoracotomy) to 593 ± 91 pg/mL. Four of five patients showed facial flushing and palmar erythema. Arterial blood pressure returned to pretraction value, and both the facial flushing and palmar erythema disappeared within 30 min after lung traction. These results suggest that traction of the lung stimulates release and/or production of prostacyclin, which results in facial flushing, palmar erythema, and decrease in arterial blood pressure.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1992 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1992 by the International Anesthesia Research Society.