JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takeda, S.
Right arrow Articles by Ogawa, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takeda, S.
Right arrow Articles by Ogawa, R.

Anesthesia & Analgesia, Vol 84, 1091-1096, Copyright © 1997 by International Anesthesia Research Society

GENERAL ARTICLES

The effect of nasal continuous positive airway pressure on plasma endothelin-1 concentrations in patients with severe cardiogenic pulmonary edema

S Takeda, T Takano and R Ogawa
Department of Intensive Care Medicine, Nippon Medical School, Tokyo, Japan.

We investigated the effects of nasal continuous positive airway pressure (CPAP) on plasma endothelin-1 (ET-1) concentrations in patients with cardiogenic pulmonary edema. Thirty patients were randomly assigned to two groups: 15 patients who received oxygen plus nasal CPAP (CPAP group), and 15 patients who received only oxygen by face mask (oxygen group). The heart rate and the mean pulmonary artery pressure decreased significantly in the CPAP group. The PaO2/ fraction of inspired oxygen (FIO2) ratio increased in the CPAP group (163 +/- 70 to 332 +/- 104, P < 0.01) after 6 h and was significantly higher than that in the oxygen group. Arterial plasma ET-1 concentrations decreased from 6.2 +/- 2.0 pg/mL to 4.8 +/- 1.7 pg/mL (P < 0.05) after 6 h and to 3.3 +/- 0.7 pg/mL (P < 0.01) after 24 h in the CPAP group. Arterial plasma ET-1 concentrations in the CPAP group compared with the oxygen group were significantly lower at 24 h. There was a correlation between the arterial plasma ET-1 concentrations and mean pulmonary artery pressure (r = 0.62, P < 0.001), and PaO2/FIO2 (r = -0.46, P < 0.01). Nasal CPAP led to an early decrease in plasma ET-1 concentrations, and improvement in oxygenation and hemodynamics.


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
S. Akada, S. Takeda, Y. Yoshida, K. Nakazato, M. Mori, T. Hongo, K. Tanaka, and A. Sakamoto
The Efficacy of Dexmedetomidine in Patients with Noninvasive Ventilation: A Preliminary Study
Anesth. Analg., July 1, 2008; 107(1): 167 - 170.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. Masip, M. Roque, B. Sanchez, R. Fernandez, M. Subirana, and J. A. Exposito
Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema: Systematic Review and Meta-analysis
JAMA, December 28, 2005; 294(24): 3124 - 3130.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
C.A. Kelly, D.E. Newby, T.A. Mcdonagh, T.W. Mackay, J. Barr, N.A. Boon, H.J. Dargie, and N.J. Douglas
Randomised controlled trial of continuous positive airway pressure and standard oxygen therapy in acute pulmonary oedema. Effects on plasma brain natriuretic peptide concentrations
Eur. Heart J., September 1, 2002; 23(17): 1379 - 1386.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1997 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1997 by the International Anesthesia Research Society.