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REGIONAL ANESTHESIA AND PAIN MANAGEMENT

Changes in Rat Paw Perfusion After Experimental Mononeuropathy: Assessment by Laser Doppler Fluxmetry

Allen H. Hord, MD^*,, Donald D. Denson, PhD^*, Michael J. Huerkamp, DVM, and John G. Seiler, III, MD

Departments of *Anesthesiology and Orthopaedics and Division of Animal Resources, Emory University School of Medicine, Atlanta, Georgia

Address correspondence and reprint requests to Allen H. Hord, MD, Department of Anesthesiology, Emory University School of Medicine, 1364 Clifton Rd. NE, Atlanta, GA 30322.

This study was performed to determine the changes in perfusion that occur after chronic constriction injury (CCI). Male Sprague-Dawley rats weighing 275–300 g had loosely constricting ligatures placed around the left sciatic nerve. Paw withdrawal latency (PWL) to heat, skin temperature, and skin perfusion (laser Doppler) of the hind paws were measured before and for 30 days after CCI. PWL decreased significantly on the side of the CCI (maximum of 34% decrease on Postoperative Day [POD] 3), then returned to normal over a 20-day period. Skin temperature initially increased on the side of CCI, then decreased with respect to the control limb on PODs 20–30. Despite the initial increase in skin temperature on the side of CCI, skin perfusion significantly decreased immediately after CCI (maximum of 51% decrease on POD 6). The perfusion gradually returned to normal over 20 days. Because return to normal perfusion occurred while the skin temperature became colder than the control side, we conclude that there is no relationship between paw surface temperature and perfusion.

Implications: Our data suggest that loss of sympathetic tone in thermoregulatory arteriovenous anastomoses leads to decreased nutritional blood flow to the skin of the affected limb after chronic constriction injury, which is consistent with the findings reported in humans with reflex sympathetic dystrophy.

This article has been cited by other articles:

				A. H. Hord, A. G. Chalfoun, D. D. Denson, and M. I. Azevedo Systemic Tizanidine Hydrochloride (ZanaflexTM) Relieves Thermal Hyperalgesia in Rats with an Experimental Mononeuropathy Anesth. Analg., November 1, 2001; 93(5): 1310 - 1315. [Abstract] [Full Text] [PDF]

				A. H. Hord, D. D. Denson, B. Stowe, and R. M. Haygood {{alpha}}-1 and {{alpha}}-2 Adrenergic Antagonists Relieve Thermal Hyperalgesia in Experimental Mononeuropathy from Chronic Constriction Injury Anesth. Analg., June 1, 2001; 92(6): 1558 - 1562. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999