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Anesth Analg 1999;88:654
© 1999 International Anesthesia Research Society

GENERAL ARTICLES

Rabbits Treated with Chronic Isepamicin Are Resistant to Mivacurium and Rocuronium

Kyo S. Kim, MD, PhD*, Jae C. Shim, MD, PhD*, Jong H. Jun, MD, PhD*, Kwang H. Lee, MD, PhD{dagger}, and Chang W. Chung, MD{ddagger}

Departments of *Anesthesiology and {dagger}Orthopaedic Surgery, Hanyang University; and {ddagger}Department of Anesthesiology, Kwandong University, Seoul, Korea

Address correspondence and reprint requests to Kyo S. Kim, MD, Department of Anesthesiology, Hanyang University Hospital, 17 Haengdang dong, Songdong-Ku, Seoul 133–792, Korea.

We compared the dose-response relationships and the neuromuscular blocking effects of mivacurium and rocuronium after chronic isepamicin therapy for 7 days in 56 anesthetized rabbits. Train-of-four stimuli were applied every 10 s to the common peroneal nerve, and the force of contraction of the tibialis anterior muscle was measured. Chronic isepamicin therapy is associated with a rightward shift of the mivacurium and rocuronium dose-response curves. The effective dose for 50% twitch depression of mivacurium and rocuronium increased significantly, from 16.9 ± 4.8 and 56.5 ± 5.3 µg/kg, respectively, with placebo to 30.6 ± 5.3 and 75.6 ± 4.7 µg/kg, respectively, during isepamicin therapy. The isepamicin rabbits receiving mivacurium 0.18 mg/kg or rocuronium 0.6 mg/kg had an accelerated recovery from neuromuscular blockade compared with those receiving placebo. The results of this study show that mivacurium and rocuronium have both a decreased effect and a shorter duration of action in rabbits when used during concurrent isepamicin therapy.

Implications: We studied the dose-response relationships and the neuromuscular blocking effects of mivacurium and rocuronium during chronic isepamicin therapy in rabbits. Mivacurium and rocuronium have both a decreased effect and a shorter duration of action during chronic aminoglycoside antibiotic therapy in rabbits.




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 Anesth. Analg.Home page
K. S. Kim, J. W. Jeon, M. S. Koh, J. H. Shim, S. Y. Cho, and J. K. Suh
The Duration of Immobilization Causes the Changing Pharmacodynamics of Mivacurium and Rocuronium in Rabbits
Anesth. Analg., February 1, 2003; 96(2): 438 - 442.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1999 by the International Anesthesia Research Society.