JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, K. S.
Right arrow Articles by Chung, C. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, K. S.
Right arrow Articles by Chung, C. W.
Anesth Analg 1999;88:654
© 1999 International Anesthesia Research Society


GENERAL ARTICLES

Rabbits Treated with Chronic Isepamicin Are Resistant to Mivacurium and Rocuronium

Kyo S. Kim, MD, PhD*, Jae C. Shim, MD, PhD*, Jong H. Jun, MD, PhD*, Kwang H. Lee, MD, PhD{dagger}, and Chang W. Chung, MD{ddagger}

Departments of *Anesthesiology and {dagger}Orthopaedic Surgery, Hanyang University; and {ddagger}Department of Anesthesiology, Kwandong University, Seoul, Korea

Address correspondence and reprint requests to Kyo S. Kim, MD, Department of Anesthesiology, Hanyang University Hospital, 17 Haengdang dong, Songdong-Ku, Seoul 133–792, Korea.

We compared the dose-response relationships and the neuromuscular blocking effects of mivacurium and rocuronium after chronic isepamicin therapy for 7 days in 56 anesthetized rabbits. Train-of-four stimuli were applied every 10 s to the common peroneal nerve, and the force of contraction of the tibialis anterior muscle was measured. Chronic isepamicin therapy is associated with a rightward shift of the mivacurium and rocuronium dose-response curves. The effective dose for 50% twitch depression of mivacurium and rocuronium increased significantly, from 16.9 ± 4.8 and 56.5 ± 5.3 µg/kg, respectively, with placebo to 30.6 ± 5.3 and 75.6 ± 4.7 µg/kg, respectively, during isepamicin therapy. The isepamicin rabbits receiving mivacurium 0.18 mg/kg or rocuronium 0.6 mg/kg had an accelerated recovery from neuromuscular blockade compared with those receiving placebo. The results of this study show that mivacurium and rocuronium have both a decreased effect and a shorter duration of action in rabbits when used during concurrent isepamicin therapy.

Implications: We studied the dose-response relationships and the neuromuscular blocking effects of mivacurium and rocuronium during chronic isepamicin therapy in rabbits. Mivacurium and rocuronium have both a decreased effect and a shorter duration of action during chronic aminoglycoside antibiotic therapy in rabbits.




This article has been cited by other articles:


Home page
Anesth. Analg.Home page
K. S. Kim, J. W. Jeon, M. S. Koh, J. H. Shim, S. Y. Cho, and J. K. Suh
The Duration of Immobilization Causes the Changing Pharmacodynamics of Mivacurium and Rocuronium in Rabbits
Anesth. Analg., February 1, 2003; 96(2): 438 - 442.
[Abstract] [Full Text] [PDF]




Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1999 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1999 by the International Anesthesia Research Society.