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GENERAL ARTICLES

Rabbits Treated with Chronic Isepamicin Are Resistant to Mivacurium and Rocuronium

Kyo S. Kim, MD, PhD^*, Jae C. Shim, MD, PhD^*, Jong H. Jun, MD, PhD^*, Kwang H. Lee, MD, PhD, and Chang W. Chung, MD

Departments of *Anesthesiology and Orthopaedic Surgery, Hanyang University; and Department of Anesthesiology, Kwandong University, Seoul, Korea

Address correspondence and reprint requests to Kyo S. Kim, MD, Department of Anesthesiology, Hanyang University Hospital, 17 Haengdang dong, Songdong-Ku, Seoul 133–792, Korea.

We compared the dose-response relationships and the neuromuscular blocking effects of mivacurium and rocuronium after chronic isepamicin therapy for 7 days in 56 anesthetized rabbits. Train-of-four stimuli were applied every 10 s to the common peroneal nerve, and the force of contraction of the tibialis anterior muscle was measured. Chronic isepamicin therapy is associated with a rightward shift of the mivacurium and rocuronium dose-response curves. The effective dose for 50% twitch depression of mivacurium and rocuronium increased significantly, from 16.9 ± 4.8 and 56.5 ± 5.3 µg/kg, respectively, with placebo to 30.6 ± 5.3 and 75.6 ± 4.7 µg/kg, respectively, during isepamicin therapy. The isepamicin rabbits receiving mivacurium 0.18 mg/kg or rocuronium 0.6 mg/kg had an accelerated recovery from neuromuscular blockade compared with those receiving placebo. The results of this study show that mivacurium and rocuronium have both a decreased effect and a shorter duration of action in rabbits when used during concurrent isepamicin therapy.

Implications: We studied the dose-response relationships and the neuromuscular blocking effects of mivacurium and rocuronium during chronic isepamicin therapy in rabbits. Mivacurium and rocuronium have both a decreased effect and a shorter duration of action during chronic aminoglycoside antibiotic therapy in rabbits.

This article has been cited by other articles:

				K. S. Kim, J. W. Jeon, M. S. Koh, J. H. Shim, S. Y. Cho, and J. K. Suh The Duration of Immobilization Causes the Changing Pharmacodynamics of Mivacurium and Rocuronium in Rabbits Anesth. Analg., February 1, 2003; 96(2): 438 - 442. [Abstract] [Full Text] [PDF]