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AMBULATORY ANESTHESIA

Postoperative Analgesia for Outpatient Arthroscopic Knee Surgery with Intraarticular Clonidine

Department of Anesthesiology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts

Address correspondence and reprint requests to Scott S. Reuben, MD, Department of Anesthesiology, Baystate Medical Center, 759 Chestnut St., Springfield, MA 01199. Address e-mail to scott.reuben @bhs.org.

Intraarticular (IA) local anesthetics are often used for the management and prevention of pain after arthroscopic knee surgery. Clonidine prolongs the duration of local anesthetics. We designed this study to determine whether clonidine added to an IA injection would result in an analgesic benefit. Fifty patients were randomly assigned to one of five groups that received clonidine (either via the subcutaneous or IA route) or saline placebo with or without IA bupivacaine, as follows: Group 1 received 30 mL of 0.25% bupivacaine IA; Group 2 received 30 mL of 0.25% bupivacaine with clonidine (1 µg/kg) IA; Group 3 received 30 mL of 0.25% bupivacaine IA and subcutaneous clonidine (1 µg/kg); Group 4 received 30 mL of 0.25% bupivacaine with epinephrine (5 µg/mL) IA; and Group 5 received clonidine (1 µg/kg) in 30 mL of saline IA. The results of this study revealed a significant difference in analgesia from the IA administration of clonidine. The group who received a combination of IA bupivacaine and clonidine had a significantly decreased need for oral postoperative analgesics and an increased analgesic duration (P < 0.0001). We conclude that IA clonidine improved comfort in patients undergoing knee arthroscopy.

Implications: The intraarticular administration of clonidine along with bupivacaine results in a significant improvement in analgesia compared with either drug alone. There was an increased time to first analgesic request and a decreased need for postoperative analgesics.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999