This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Vidovich, M. I. Articles by Wong, H. Y. Search for Related Content PubMed PubMed Citation Articles by Vidovich, M. I. Articles by Wong, H. Y.

---

GENERAL ARTICLES

The Effect of Lidocaine on Bacterial Growth in Propofol

Mladen I. Vidovich, MD^*, Lance R. Peterson, MD, and Hak Y. Wong, MBBS^*

Departments of *Anesthesiology and Pathology, Northwestern University Medical School, Chicago, Illinois

Address correspondence and reprint requests to Mladen I. Vidovich, MD, Passavant Pavilion, Suite 360, 303 East Superior St., Chicago, IL 60611. Address e-mail to miv909{at}nwu.edu

Extrinsically contaminated propofol has been associated with multiple infectious complications. Injection of propofol is associated with pain that is diminished by the addition of lidocaine. Lidocaine has antibacterial properties at high concentrations, but low concentrations of lidocaine (0.1%) have not been studied. We examined the growth rates of Staphylococcus aureus, Serratia marcescens, Pseudomonas aeruginosa, and Candida albicans in propofol containing disodium edeteate with and without added lidocaine 0.1% 2, 5, and 24 h after inoculation. There was no significant difference in the number of colony-forming units between propofol with and without added lidocaine at any time after inoculation.

Implications: The addition of lidocaine to propofol in concentrations clinically effective in reducing pain on injection had no effect on microbial growth. Adherence to strict aseptic technique is further emphasized.

This article has been cited by other articles:

				C. Stucki, A.-M. Sautter, J. Favet, and P. Bonnabry Microbial contamination of syringes during preparation: The direct influence of environmental cleanliness and risk manipulations on end-product quality Am. J. Health Syst. Pharm., November 15, 2009; 66(22): 2032 - 2036. [Abstract] [Full Text] [PDF]

				Y. Masaki, M. Tanaka, and T. Nishikawa Physicochemical Compatibility of Propofol-Lidocaine Mixture Anesth. Analg., December 1, 2003; 97(6): 1646 - 1651. [Abstract] [Full Text] [PDF]

				R. P. Driver Jr., D. T. Jolly, I. Wachowski, J. Hrazdil, and J. C. Galbraith Conclusions Regarding Propofol/Lidocaine Admixture May Be Misleading • Response Anesth. Analg., November 1, 1999; 89(5): 1331 - 1331. [Full Text] [PDF]