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Anesth Analg 1999;88:936
© 1999 International Anesthesia Research Society

GENERAL ARTICLES

The Effect of Lidocaine on Bacterial Growth in Propofol

Mladen I. Vidovich, MD*, Lance R. Peterson, MD{dagger}, and Hak Y. Wong, MBBS*

Departments of *Anesthesiology and {dagger}Pathology, Northwestern University Medical School, Chicago, Illinois

Address correspondence and reprint requests to Mladen I. Vidovich, MD, Passavant Pavilion, Suite 360, 303 East Superior St., Chicago, IL 60611. Address e-mail to miv909{at}nwu.edu

Extrinsically contaminated propofol has been associated with multiple infectious complications. Injection of propofol is associated with pain that is diminished by the addition of lidocaine. Lidocaine has antibacterial properties at high concentrations, but low concentrations of lidocaine (0.1%) have not been studied. We examined the growth rates of Staphylococcus aureus, Serratia marcescens, Pseudomonas aeruginosa, and Candida albicans in propofol containing disodium edeteate with and without added lidocaine 0.1% 2, 5, and 24 h after inoculation. There was no significant difference in the number of colony-forming units between propofol with and without added lidocaine at any time after inoculation.

Implications: The addition of lidocaine to propofol in concentrations clinically effective in reducing pain on injection had no effect on microbial growth. Adherence to strict aseptic technique is further emphasized.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1999 by the International Anesthesia Research Society.