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GENERAL ARTICLES

The Effect of Tenoxicam on Intraperitoneal Adhesions and Prostaglandin E₂ Levels in Mice

Bilge Celebioglu, MD^*, Nima Ramzi Eslambouli, MD^*, Ekmel Olcay, MD, and afak Atakan, MD

*Department of Anesthesiology, School of Medicine, Hacettepe University; Department of Pharmacology, Hifsizsihha Institution; and Department of Pathology, School of Medicine, Ankara University, Ankara, Turkey

Address correspondence and reprint requests to Bilge Celebioglu, MD, Department of Anesthesiology, Çatal sokak 12/4 Maltepe 06570, Ankara, Turkey.

We determined whether tenoxicam administered intraperitoneally in the preoperative period had an effect on the development of postoperative intraabdominal adhesions (IAA). For this purpose, 100 albino mice were divided into four random groups. Mice in Group 1 were given only 1 mL of 0.9% NaCl intraperitoneally, whereas in Group 2, 1 mL of tenoxicam (150 µg = 5 mg/kg) was administered. After the induction of anesthesia, a median laparotomy was performed, and the bowels were traumatized by touching them with powdered gloves before the incision was closed in Groups 3 and 4. Intraperitoneal tenoxicam was administered to mice in Group 4 after skin closure. All mice were killed after 14 days to determine macroscopic and microscopic IAA; prostaglandin E₂ levels were also measured. Postoperative evaluation revealed a reduced IAA formation and a parallel decrease in tissue prostaglandin E₂ levels in Group 1 and 2 mice. We conclude that intraperitoneal tenoxicam decreased IAA formation with no peritoneal reaction in the postoperative period.

Implications: Postoperative intraabdominal adhesions can cause intestinal obstruction, pelvic pain, or infertility. In this study, we showed that intraperitoneally administered tenoxicam decreases tissue prostaglandin E₂ levels and intraabdominal adhesions in mice.

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