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CARDIOVASCULAR ANESTHESIA

Cerebral Production of Adrenomedullin After Hypothermic Cardiopulmonary Bypass in Adult Cardiac Surgical Patients

Satoki Inoue, MD^*, Yukio Hayashi, MD^*, Yoshihiko Ohnishi, MD^*, Katsuro Kikumoto, MD^*, Naoto Minamino, PhD, Kenji Kangawa, PhD, Hisayuki Matsuo, PhD, Hitoshi Furuya, MD, and Masakazu Kuro, MD^*

*Department of Anesthesiology, National Cardiovascular Center, Osaka; National Cardiovascular Center Research Institute, Osaka; and Department of Anesthesiology, Nara Medical University, Nara, Japan

Address correspondence and reprint requests to Satoki Inoue, Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634, Japan.

Adrenomedullin is a potent vasodilatory peptide originally identified in human pheochromocytoma. Plasma adrenomedullin increases during and after cardiopulmonary bypass (CPB). However, the site at which production of adrenomedullin is augmented has not been identified. In the present study, we examined the contribution of the cerebral vasculature to the production of adrenomedullin in patients before, during, and after CPB. Ten patients undergoing coronary artery bypass grafting with mild hypothermic CPB were studied. Cerebral blood flow was measured using the Kety-Schmidt method before, during, and after CPB. Plasma adrenomedullin concentrations from radial artery and internal jugular bulb blood were measured by radioimmunoassay, and cerebral adrenomedullin production was evaluated. Adrenomedullin production in the cerebral vasculature was significantly enhanced after CPB and correlated with aortic cross-clamping time. The cerebral adrenomedullin production may contribute to the increased plasma level of adrenomedullin after CPB.

Implications: Plasma adrenomedullin has been reported to increase in humans after cardiac surgery involving cardiopulmonary bypass. In this study, we demonstrated that cerebral adrenomedullin production may contribute to the increased plasma level of adrenomedullin after cardiopulmonary bypass.

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