| JOURNAL HOME | CME HOME | THIS MONTH | PAST ISSUES | ETOC | COLLECTIONS |
| AUTHORS | REVIEWERS | EDITORIAL BOARD | FEEDBACK | RSS | HELP |
| ||||||||||||||
| ||||||||||||||
|
|
|
|
||||||||||||
|
||||||||||||||
Departments of
*Anesthesiology and
Surgery, Tri-Service General Hospital, National Defense Medical Center; and
Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan
Address correspondence and reprint requests to Jhi-Joung Wang, MD, DMSc, Department of Anesthesiology, Tri-Service General Hospital/National Defense Medical Center, No. 8, Sec. 3, Ting-Chow Rd., Taipei, Taiwan. Address e-mail to painlab{at}tpts5.seed.net.tw
The aim of this study was to evaluate the prophylactic effect of dexamethasone on postoperative nausea and vomiting (PONV) in women undergoing thyroidectomy. Droperidol and saline served as controls. One hundred twenty women (n = 40 in each of three groups) undergoing thyroidectomy under general anesthesia were enrolled in this randomized, double-blinded, placebo-controlled study. Immediately before the induction of anesthesia, Group 1 received IV dexamethasone 10 mg, whereas Groups 2 and 3 received IV droperidol 1.25 mg and saline, respectively. We found that both dexamethasone and droperidol significantly decreased the total incidence of PONV compared with saline, with an incidence of 32%, 35%, and 76%, respectively (P < 0.01; Group 1 versus Group 3, Group 2 versus Group 3). Patients who received droperidol, however, reported a higher intensity of sore throat and a more frequent incidence of restlessness than those who received dexamethasone. We conclude that, although both dexamethasone and droperidol are effective as prophylactic antiemetics in women undergoing thyroidectomy, droperidol produces more side effects.
Implications: We compared the prophylactic administration of dexamethasone to prevent nausea and vomiting with droperidol and saline in women undergoing thyroidectomy. Both dexamethasone and droperidol significantly reduced postoperative nausea and vomiting, but droperidol produced more side effects, which suggests that dexamethasone is a useful treatment in these patients.
This article has been cited by other articles:
|
|
 |
|
  J. Wallenborn, G. Gelbrich, D. Bulst, K. Behrends, H. Wallenborn, A. Rohrbach, U. Krause, T. Kuhnast, M. Wiegel, and D. Olthoff Prevention of postoperative nausea and vomiting by metoclopramide combined with dexamethasone: randomised double blind multicentre trial BMJ, August 12, 2006; 333(7563): 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-A. Nortcliffe, J. Shah, and D. J. Buggy Prevention of postoperative nausea and vomiting after spinal morphine for Caesarean section: comparison of cyclizine, dexamethasone and placebo Br. J. Anaesth., May 1, 2003; 90(5): 665 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-T. Ho, J.-J. Wang, J.-I. Tzeng, H.-S. Liu, L.-P. Ger, and W.-J. Liaw Dexamethasone for Preventing Nausea and Vomiting Associated with Epidural Morphine: A Dose-Ranging Study Anesth. Analg., March 1, 2001; 92(3): 745 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Tzeng, J. J. Wang, S. T. Ho, C. S. Tang, Y. C. Liu, and S. C. Lee Dexamethasone for prophylaxis of nausea and vomiting after epidural morphine for post-Caesarean section analgesia: comparison of droperidol and saline Br. J. Anaesth., December 1, 2000; 85(6): 865 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Wang, S.-T. Ho, S.-C. Lee, Y.-C. Liu, and C.-M. Ho The Use of Dexamethasone for Preventing Postoperative Nausea and Vomiting in Females Undergoing Thyroidectomy: A Dose-Ranging Study Anesth. Analg., December 1, 2000; 91(6): 1404 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Wang, S.-T. Ho, J.-I. Tzeng, and C.-S. Tang The Effect of Timing of Dexamethasone Administration on Its Efficacy as a Prophylactic Antiemetic for Postoperative Nausea and Vomiting Anesth. Analg., July 1, 2000; 91(1): 136 - 139. [Abstract] [Full Text] [PDF]
|
|
|
