Anesth Analg 1999;89:476
© 1999 International Anesthesia Research Society
GENERAL ARTICLES
Comparison of Ramosetron and Granisetron for Preventing Postoperative Nausea and Vomiting After Gynecologic Surgery
Yoshitaka Fujii, MD*,
Yuhji Saitoh, MD ,
Hiroyoshi Tanaka, MD , and
Hidenori Toyooka, MD*
Departments of Anesthesiology,
*University of Tsukuba Institute of Clinical Medicine, Tsukuba City; and
Toride Kyodo General Hospital, Toride City, Ibaraki, Japan
Address correspondence and reprint requests to Y. Fujii, Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, 21-1, Amakubo, Tsukuba City, Ibaraki 305, Japan.
In a prospective, randomized, double-blinded study, we evaluated the efficacy of granisetron and ramosetron for preventing postoperative nausea and vomiting (PONV) in major gynecologic surgery. One hundred twenty patients, ASA physical status I or II, aged 2365 yr, received IV granisetron 2.5 mg or ramosetron 0.3 mg (n = 60 each) at the end of surgery. A standard general anesthetic technique and postoperative analgesia were used. The incidence of a complete response, defined as no PONV and no need for another rescue medication, 03 h after anesthesia was 87% with granisetron and 90% with ramosetron; the corresponding incidence 324 h after anesthesia was 85% and 90%; the corresponding incidence 2448 h after anesthesia was 70% and 92% (P < 0.05). No clinically serious adverse events due to the drugs were observed in any of the groups. In conclusion, prophylactic therapy with ramosetron is more effective than granisetron for the long-term prevention of PONV after major gynecologic surgery.
Implications: We compared the efficacy of granisetron and ramosetron for preventing postoperative nausea and vomiting in major gynecologic surgery. Prophylactic therapy with ramosetron was more effective than granisetron for preventing postoperative nausea and vomiting 2448 h after anesthesia.
This article has been cited by other articles:

|
 |

|
 |
 
S. I. Kim, S. C. Kim, Y. H. Baek, S. Y. Ok, and S. H. Kim
Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery
Br. J. Anaesth.,
October 1, 2009;
103(4):
549 - 553.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Fujii, H. Tanaka, and M. Ito
Ramosetron compared with granisetron for the prevention of vomiting following strabismus surgery in children
Br J Ophthalmol,
June 1, 2001;
85(6):
670 - 672.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Kranke, C. C. Apfel, N. Roewer, and Y. Fujii
Reported Data on Granisetron and Postoperative Nausea and Vomiting by Fujii et al. Are Incredibly Nice! • Response
Anesth. Analg.,
April 1, 2000;
90(4):
1004 - 1007.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Fujii, Y. Saitoh, H. Tanaka, and H. Toyooka
Ramosetron for Preventing Postoperative Nausea and Vomiting in Women Undergoing Gynecological Surgery
Anesth. Analg.,
February 1, 2000;
90(2):
472 - 472.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|