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CARDIOVASCULAR ANESTHESIA

Isoflurane Administration Before Ischemia and During Reperfusion Attenuates Ischemia/Reperfusion-Induced Injury of Isolated Rabbit Lungs

Renyu Liu, MD^*, Yuichi Ishibe, MD, PhD^*, Mayumi Ueda, MD^*, and Yannan Hang, MD

*Department of Anesthesiology and Reanimatology, Tottori University Faculty of Medicine, Yonago, Japan; and Department of Anesthesiology, Renji Hospital, Shanghai Second Medical University, Shanghai, China

Address correspondence and reprint requests to Yuichi Ishibe, MD, Department of Anesthesiology and Reanimatology, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan. Address e-mail to ishibe{at}grape.med.tottori-u.ac.jp

To investigate the effects of isoflurane on ischemia/reperfusion (IR)-induced lung injury, we administered isoflurane before ischemia or during reperfusion. Isolated rabbit lungs were divided into the following groups: control (

n = 6), perfused and ventilated for 120 min without ischemia; ISO-control (n = 6), 1 minimum alveolar anesthetic concentration (MAC) isoflurane was administered for 30 min before 120 min continuous perfusion; IR (n = 6), ischemia for 60 min, followed by 60 min reperfusion; IR-ISO1 and IR-ISO2, ischemia followed by reperfusion and 1 MAC (n = 6) or 2 MAC (n = 6) isoflurane for 60 min; ISO-IR (n = 6), 1 MAC isoflurane was administered for 30 min before ischemia, followed by IR. During these maneuvers, we measured total pulmonary vascular resistance (Rt), coefficient of filtration (Kfc), and lung wet to dry ratio (W/D). The results indicated that administration of isoflurane during reperfusion inhibited an IR-induced increase in Kfc and W/D ratio. Furthermore, isoflurane at 2 MAC, but not 1 MAC, significantly inhibited an IR-induced increase in Rt. The administration of isoflurane before ischemia significantly attenuated the increase in IR-induced Kfc, W/D, and Rt.

Implications: Our results suggest that the administration of isoflurane before ischemia and during reperfusion protects against ischemia-reperfusion-induced injury in isolated rabbit lungs.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999