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CARDIOVASCULAR ANESTHESIA

Fast-Track Cardiac Anesthesia in Patients with Sickle Cell Abnormalities

Department of Anesthesia, The Toronto Hospital, University of Toronto, Toronto, Ontario, Canada

Address correspondence and reprint requests to Dr. Davy C. H. Cheng, Department of Anesthesia, The Toronto Hospital, Bell Wing 4-646, 585 University Ave., Toronto, Ontario, Canada M5G 2C4. Address e-mail to davycheng{at}compuserve.com

We conducted a retrospective review of 10 patients with sickle cell trait (SCT) and 30 patients (cohort control) without SCT undergoing first-time coronary artery bypass graft surgery with cardiopulmonary bypass. Demographic, perioperative management, and outcome data were collected. Both groups were matched according to age, weight, duration of surgery, and preoperative hemoglobin (Hb) concentration. Distribution of gender, medical conditions, pharmacological treatment, and preoperative left ventricular function were similar between the groups. The comparisons were analyzed in respect to postoperative blood loss and transfusion rates, as well as duration of intubation, intensive care unit, and hospital length of stay (LOS). All patients underwent fast-track cardiac anesthesia. A combination of cold crystalloid and blood cardioplegia was used. The lowest nasopharyngeal temperature was 33°C. There were no episodes of significant hypoxemia, hypercarbia, or acidosis. None of the patients had sickling crisis during the perioperative period. The postoperative blood loss was 687 ± 135 vs 585 ± 220 mL in the SCT and control groups, respectively. The trigger for blood transfusion during cardiopulmonary bypass was hematocrit <20% and Hb <75 g/L postoperatively. Three SCT patients (30%) and 10 control patients (33%) received a blood transfusion. Median extubation time was 4.0 vs 3.9 h; intensive care unit LOS was 27 vs 28 h; and hospital LOS was 6.0 vs 5.5 days in the SCT and control groups, respectively. There were no intraoperative deaths. One patient in the SCT group died from multiorgan failure 2 mo after surgery.

Implications: Fast-track cardiac anesthesia can be used safely in patients with sickle cell trait undergoing first-time coronary artery bypass graft surgery. Extubation time and intensive care unit and hospital length of stay are comparable to those of matched controls, and blood loss and transfusion requirements are not increased. A hematocrit of 20% seems to be a safe transfusion trigger during cardiopulmonary bypass in these patients.

This article has been cited by other articles:

				M. M Maddali, M. C Rajakumar, J. Fahr, M. J Albahrani, and M. A Amna Cardiopulmonary Bypass Without Preoperative Exchange Transfusion in Sicklers Asian Cardiovasc Thorac Ann, February 1, 2006; 14(1): 51 - 56. [Abstract] [Full Text] [PDF]

				R. C. Prielipp, J. F. Butterworth, G. N. Djaiani, and D. C. H. Cheng Clinical Guidelines • Response Anesth. Analg., February 1, 2000; 90(2): 503 - 503. [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999