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CARDIOVASCULAR ANESTHESIA

Cerebral Response to Hemodilution During Hypothermic Cardiopulmonary Bypass in Adults

Hulya Sungurtekin, MD^*, David J. Cook, MD, Thomas A. Orszulak, MD, Richard C. Daly, MD, and Charles J. Mullany, MD

*Pamukkale University Medical School, Denizli, Turkey; and Departments of Anesthesiology and Surgery, Mayo Medical School, Rochester, Minnesota

Address correspondence and reprint requests to David J. Cook, MD, 200 First St., SW, Rochester, MN 55905. Address e-mail to cook.david{at}mayo.edu

We examined the cerebral response to changing hematocrit during hypothermic cardiopulmonary bypass (CPB) in 18 adults. Cerebral blood flow (CBF), cerebral metabolic rate for oxygen (CMRO₂), and cerebral oxygen delivery (CDO₂) were determined using the nitrous oxide saturation technique. Measurements were obtained before CPB at 36°C, and twice during 27°C CPB: first with a hemoglobin (Hgb) of 6.2 ± 1.2 g/dL and then with a Hgb of 8.5 ± 1.2 g/dL. During hypothermia, appropriate reductions in CMRO₂ were demonstrated, but hemodilution-associated increases in CBF offset the reduction in CBF seen with hypothermia. At 27°C CPB, as the Hgb concentration was increased from 6.2 to 8.5 g/dL, CBF decreased. CDO₂ and CMRO₂ were no different whether the Hgb was 6.2 or 8.5 g/dL. In eight patients in whom the Hgb was less than 6 g/dL, CDO₂ remained more than twice CMRO₂.

Implications: This study suggests that cerebral oxygen balance during cardiopulmonary bypass is well maintained at more pronounced levels of hemodilution than are typically practiced, because changes in cerebral blood flow compensate for changes in hemoglobin concentration.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999