JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kulier, A. H.
Right arrow Articles by Bosnjak, Z. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kulier, A. H.
Right arrow Articles by Bosnjak, Z. J.
Anesth Analg 1999;89:1393
© 1999 International Anesthesia Research Society

CARDIOVASCULAR ANESTHESIA

The Effects of the New Antiarrhythmic E 047/1 on Postoperative Ischemia-Induced Arrhythmias in Dogs

Alexander H. Kulier, MD, Enis Novalija, MD, Quinn Hogan, MD, Martin N. Vicenzi, MD, Harvey J. Woehlck, MD, Jurica Bajic, MD, John L. Atlee, III, MD, and Zeljko J. Bosnjak, PhD

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Address correspondence and reprint requests to Alexander Kulier, MD, LKH Graz, Department of Anesthesiology, Auenbruggerplatz 15, A-8036 Graz, Austria.

Perioperative malignant ventricular tachyarrhythmias pose an imminent clinical danger by potentially precipitating myocardial ischemia and severely compromising hemodynamics. Thus, immediate and effective therapy is required, which is not always provided by currently recommended IV drug regimens, indicating a need for more effective drugs. We examined antiarrhythmic effects of the new benzofurane compound E 047/1 on spontaneous ventricular tachyarrhythmia in a conscious dog model. One day after experimental myocardial infarction, 40 dogs exhibiting tachyarrhythmia randomly received (bolus plus 1-h infusion) E 047/1 6 mg/kg plus 6 mg · kg-1 · h-1, lidocaine 1 mg/kg plus 4.8 mg · kg-1 · h-1, flecainide 1 mg/kg plus 0.05 mg · kg-1 · h-1, amiodarone 10 mg/kg plus 1.8 mg · kg-1 · h-1, or bretylium 10 mg/kg plus 20 mg · kg-1 · h-1. Electrocardiogram was evaluated for number of premature ventricular contractions (PVC), normally conducted beats originating from the sinoatrial node, and episodes of ventricular tachycardia. Immediately after the bolus, E 047/1 reduced PVCs by 46% and increased sinoatrial beats from 4 to 61 bpm. The ratio of PVCs to total beats decreased from 98% to 58%. Amiodarone and flecainide exhibited antiarrhythmic effects with delayed onset. Lidocaine did not suppress PVCs significantly, and bretylium was proarrhythmic. The antiarrhythmic E 047/1 has desirable features, suppressing ischemia-induced ventricular tachyarrhythmia quickly and efficiently, and may be a useful addition to current therapeutic regimens.

Implications: Life-threatening arrhythmias of the heart after myocardial infarction or ischemia may be treated quickly and efficiently by the new drug E 047/1.




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
M. J. P. Raatikainen, T. E. Morey, P. Druzgala, P. Milner, M. D. Gonzalez, and D. M. Dennis
Potent and Reversible Effects of ATI-2001 on Atrial and Atrioventricular Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart
J. Pharmacol. Exp. Ther., November 1, 2000; 295(2): 779 - 785.
[Abstract] [Full Text]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1999 by the International Anesthesia Research Society.