JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fujii, Y.
Right arrow Articles by Toyooka, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fujii, Y.
Right arrow Articles by Toyooka, H.
Anesth Analg 1999;89:1557
© 1999 International Anesthesia Research Society

GENERAL ARTICLES

Propofol Decreases Diaphragmatic Contractility in Dogs

Yoshitaka Fujii, MD, Takuo Hoshi, MD, Shinji Takahashi, MD, and Hidenori Toyooka, MD

Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan

Address correspondence and reprint requests Yoshitaka Fujii, MD, Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City, Ibaraki 305, Japan.

Volatile anesthetics depress diaphragmatic muscle function; however, no data are available regarding the effect of propofol on diaphragmatic contractility. We therefore studied this effect in dogs. Pentobarbital-anesthetized animals were divided into three groups of 10 each. Group I received only maintenance fluid; Group II was infused with a subhypnotic dose of propofol (0.1-mg/kg initial dose plus 1.5-mg · kg-1 · h-1 maintenance dose); Group III was infused with an anesthetic dose of propofol (0.1-mg/kg initial dose plus 6.0-mg · kg-1 · h-1 maintenance dose). We assessed diaphragmatic contractility by transdiaphragmatic pressure (Pdi). With an infusion of propofol in Groups II and III, Pdi at low-frequency (20-Hz) stimulation decreased from the baseline values (P < 0.05), whereas Pdi at high-frequency (100-Hz) stimulation did not change. Compared with Group I, Pdi at 20-Hz stimulation decreased during propofol administration in Groups II and III (P < 0.05). The decrease in Pdi was more in Group III than in Group II (P < 0.05). We conclude that propofol is associated with a dose-related inhibitory effect on diaphragmatic contractility in dogs.

Implications: Propofol is an effective IV anesthetic for the induction and maintenance of anesthesia. Subhypnotic and anesthetic doses of propofol decrease diaphragmatic contractility in dogs.




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
X.-J. Zhang, G. Yu, X.-H. Wen, Z.-C. Lin, F.-Q. Yang, Z.-G. Zheng, R.-C. Chen, and N.-S. Zhong
Effect of propofol on twitch diaphragmatic pressure evoked by cervical magnetic stimulation in patients
Br. J. Anaesth., January 1, 2009; 102(1): 61 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Fujii, A. Uemura, and H. Toyooka
The Recovery Profile of Reduced Diaphragmatic Contractility Induced by Propofol in Dogs
Anesth. Analg., July 1, 2004; 99(1): 113 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. H. Dueck, A. Oberthuer, C. Wedekind, M. Paul, and U. Boerner
Propofol Impairs the Central but Not the Peripheral Part of the Motor System
Anesth. Analg., February 1, 2003; 96(2): 449 - 455.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Fujii, A. Uemura, and H. Toyooka
The Dose-Range Effects of Propofol on the Contractility of Fatigued Diaphragm in Dogs
Anesth. Analg., November 1, 2001; 93(5): 1194 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
Y. Fujii and H. Toyooka
Midazolam versus propofol for reducing contractility of fatigued canine diaphragm
Br. J. Anaesth., June 1, 2001; 86(6): 879 - 881.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
G. Haeseler, M. Stormer, J. Bufler, R. Dengler, H. Hecker, S. Piepenbrock, and M. Leuwer
Propofol Blocks Human Skeletal Muscle Sodium Channels in a Voltage-Dependent Manner
Anesth. Analg., May 1, 2001; 92(5): 1192 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Fujii, T. Hoshi, S. Takahashi, and H. Toyooka
The Effect of Sedative Drugs on Diaphragmatic Contractility in Dogs: Propofol Versus Midazolam
Anesth. Analg., October 1, 2000; 91(4): 1035 - 1037.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1999 by the International Anesthesia Research Society.