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NEUROSURGICAL ANESTHESIA

The Hemodynamic Effects of Endothelin Receptor Antagonism During a Venous Air Infusion in Dogs

Jose Eduardo Tanus-Santos, MD, PhD^*, Wladimir Mignone Gordo, PharmD, MSc^*, Artur Udelsmann, MD, and Heitor Moreno Junior, MD, PhD^*

Departments of *Pharmacology and Anesthesiology and Research Laboratory of Anesthesia, State University of Campinas, São Paulo, Brazil

Address correspondence and reprint requests to Jose Eduardo Tanus-Santos, MD, PhD, Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, PO Box 6111, 13083-970 Campinas, São Paulo, Brazil. Address e-mail to tanus@ unicamp.br.

Endothelin (ET) is involved in the humoral component of the vasoconstriction during pulmonary embolism. We examined the effects of selective ET receptor antagonists on the hemodynamic and respiratory changes and on serum thromboxane B₂ (TXB₂) levels, during a continuous venous air infusion (VAI) in anesthetized mongrel dogs. The VAI (0.2 mL · kg^-1 · min^-1) was initiated 5 min after an injection of saline (controls, n = 7), 1 µmol of the selective ET_A receptor antagonist JKC-301 (group A, n = 6), or 1 µmol of the selective ET_B receptor antagonist BQ-788 (group B, n = 6). Hemodynamic evaluation was performed every 15 min of VAI, and blood samples were drawn for blood gas analysis and TXB₂ determinations. The increase in pulmonary perfusion pressure after 30 min of VAI was attenuated in Group A compared with the controls and Group B (Group A = 7 ± 1 mm Hg; Group B = 16 ± 1 mm Hg; controls = 14 ± 1 mm Hg; P < 0.05). Pulmonary vascular resistance showed a similar behavior. TXB₂ concentrations increased after 60 min of VAI in the controls and in Group B, but not in Group A (controls = 48%; Group B = 104%; Group A = 18%; P < 0.05 for controls and Group B). Similar decreases in PaO₂ and SaO₂ were observed in the three groups. We conclude that antagonism of ET_A receptors attenuates the hemodynamic changes and blunts the increase in thromboxane A₂ production during a VAI in dogs.

Implications: We evaluated the effects of endothelin receptor antagonists during a venous air infusion in dogs. Endothelin_A receptor antagonism attenuated the hemodynamic changes and blunted the increase in thromboxane A₂ production in this setting.

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				D. C. Souza-Costa, T. Zerbini, A. C. Palei, R. F. Gerlach, and J. E. Tanus-Santos L-arginine Attenuates Acute Pulmonary Embolism-Induced Increases in Lung Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Chest, November 1, 2005; 128(5): 3705 - 3710. [Abstract] [Full Text] [PDF]

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999